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Budhaditya Mukherjee

About


Research Statement


We are new group focusing on different aspects of infectious intracellular protozoan pathogens using LeishmaniaToxoplasma and Plasmodium as model system.  My research has always focused on different immunological and cellular aspects of parasite biology, that enables these intracellular pathogens to survive within the hostile host enviornment. My scholarship has rendered around theories and methods of protozoan parasitic diseases with applications to clinical importance. We have contributed significantly in the field of drug resistance leishmaniasis one of the major emerging problem for India with new cases reported every year. For a better understanding of protozoan mediated infectious disease I started working on Plasmodium and Toxoplasma causative agents of Malaria & Toxoplasmosis as an EMBO-Post-doctoral fellow. My post-doctoral scholarship primarily articulate in successfully characterized key factors involved in establishing successful infection and dissemination of apicomplexan parasites into or out of the host. During this peroid I also  managed a collaborative project with industrial partner UCB Pharma S.A and Medicines for Malaria Venture (MMV) to design biochemical assays for therapeutic development.
My research interest is interdisciplinary in nature, and our lab want to explore the possibility to establish a potent CRISPR-Cas9 based genome editing techniques in protozoan biology, which in turn could be implemented in characterization of key components of disease pathogenesis & intra/inter species-transmission of these intracellular pathogens. Another focus of the lab would be to develop biochemical assays for activity-based protein profiling to study parasite biology with a particular view of developing them with potential translational value for pharma industries. This should also serve as the base to challenge the existing problem of drug resistance and absence of vaccine, and help in designing of novel drug targets against these pathogens which currently is affecting a huge part of population each year.

Research

  • 1 Infectious protozoan pathogens
  • 2 Immunobiology & Cell biology
  • 3 Host-Parasite interaction
  • 4 Cell Signaling
  • 5 Biochemical assay development

Publications

  • Mukherjee B., Tessaro F. , Vahokoski J. , Kursula I. , Marq J. , Scapozza L. , Soldati-favre D., Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases, EMBO J, 98047-98062, 2018
  • Dogga S. K., Mukherjee B. , Jacot D. , Malino L. , Hammoudi P. , Hartkoorn R. , Hell A. , Soldat-favre D, A drugable secretory protein maturase of Toxoplasma essential for invasion and egress, Elife, 2017
  • Pino P., Caldelari R. , Mukherjee B. , Vahokoski J. , Klages N. , Maco B. , Collins C. ., Blackman M. J., Kursula I. , Heussler V. , Brochet M. , Soldati-favre D., A multi-stage antimalarial targets the plasmepsins IX and X essential for invasion and egress, Science, 358, 522-528, 2017
  • Mukherjee B., Paul J. , Mukherjee S. , Mukhopadhyay R. , Das S. , Naskar K. , Dujardin J. , Roy S., Antimony-Resistant Leishmania donovani Exploits miR-466i To Deactivate Host MyD88 for Regulating IL-10/IL-12 Levels during Early Hours of Infection, J. Immunol, 195, 2731-2742, 2015
  • Mukherjee S., Mukherjee B. , Mukhopadhyay R. , Naskar K. , Dujardin J. , Roy S, Imipramine exploits Histone deacetylase 11 to increase IL-12/IL-10 ratio in macrophages infected with antimony resistant Leishmania donovani and clears organ parasite in experimental infection, J. Immunol, 193, 4083-4094, 2014
  • Mukherjee B., Mukhopadhyay R. , Bannerjee B. , Chowdhury S. , Naskar K. , Allam U. , Chakravortty D. , Sundar S. , Dujardin J. , Roy S., Antimony resistant Leishmania donovani upregulates IL-10 to overexpress host multi drug resistant protein1, Proc Natl Acad Sci U S A, 110, 575-582, 2013
  • Chowdhury S., Mukherjee T. , Mukhopadhyay R. , Mukherjee B. , Sengupta S. , Chattopadhyay S. , Jaisankar P. , Roy S. , Majumder H., The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice, EMBO Mol Med, 1126-1143 (, 2012
  • Mukhopadhyay R., Mukherjee S. , Mukherjee B. , Naskar K. , Mondal D. , Decuypere S. , Ostyn B. , Prajapati V. , Sundar S. , Dujardin J. , Roy S., Characterisation of antimony-resistant Leishmania donovani isolates: biochemical and biophysical studies and interaction with host cells, Int J Parasitol, 1311-1321, 2011

Projects

  • Identification and Characterization of Proteins Involved in Transmission Machinery of Protozoan Pathogens

Awards

  • Pfizer Research Award in the area of infectious diseases, rheumatology and immunology
  • INSA Medal for Young Scientist
  • Swiss Government Excellence Scholarship
  • EMBO long term European Fellowship
  • ParaFrap International Fellowship
  • CSIR, India, National Eligibility Test (NET) PhD Fellowship

Patents

  • iMEdiX to A multi-tier secure modular system for telemedicine and e-healthcare
  • A process for fabrication of customized ceramic products by CNC machining of green ceramics compacts using diamond impregnated tool
  • A process for Production of Collagen and By-Products from Fresh Water Fish Origin and Applications
  • In situ iodination with amine/hydroxyl derivatives for non-invasive imaging and other applications thereof
  • Hybrid composite scaffold preparation and application thereof
  • Radiopaque surgical suture, mesh, stent and glue with antimicrobial property
  • Net Shape Forming via Plastic Dough Processing of Polymer-Metal Powder Blend and applications thereof
  • Long term cell tracking with inherent reactive oxygen species scavenging using biomass derived carbon nanodots (CNDs) and application thereof
  • Long term cell tracking with inherent reactive oxygen species scavenging using biomass derived carbon nanodots (CNDs) and application thereof
  • ‘Net Shape Forming via Plastic Dough Processing of Polymer-Metal Powder Blend and applications thereof’
  • Buckling assisted and lithographically micropatterned highly flexible sensors over pre-stretched surface engineered elastomers
  • iMEdiX to A multi-tier secure modular system for telemedicine and e-healthcare : Filed (Ref : )

Research Group

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Souradeepa Ghosh
Ph.D
Research Scholars
Infectious disease and immunology
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Supratim Pradhan
Ph.D
Research Scholars
Infectious disease and immunology