‘Knowledge the Continuum’' in understanding ‘homeostatic thresholds of life’ in the context of health & disease. Life is manifested in ‘multiple modes and scales’ to form ‘complex patterns’. Nourishing logically ‘Knowledge the Continuum’ with all sorts of available domain knowledge (applied, abstract, intuitive) through path of multi-disciplinary integration. Living systems become more complex essentially through the trauma connotation path. Transformation of trauma into intelligence essentially entails the embodiment of evolving systemic consciousness from the interplay of co-occurring cooperation and competition within certain thresholds which are irreversibly impaired in non-healing diseases. Systemically evolved consciousness may be comprehended in depth through more interaction with ‘mathematical abstractions’ and ‘astronomical studies’. This understanding about health and disease can be utilized to explore early diagnostic/ theranostic signatures and in developing effective therapeutic strategy /tools as well as for disease prevention. Overall this approach cultivates both fundamental and translational dimensions in medical/biomedical research.Enriched with this concept our interdisciplinary research work in the field of early diagnosis of malignant potetiality of pre-cancer/ cancer, healing of diabetic/non-healing wounds, regenerative medicines, honey as a systemic healer and Yoga-Naturopathy.In the research activity it involves in vitro and in vivo studies through employing multimodal molecular/spectroscopic/ microscopic/sub-surface/ transbody imaging and analysis, regeneratve medicine approaches with special application of honey-biomaterial based constructs/film/gels.