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Nishant Chakravorty

About


Research Statement


If life is a story, then genetics is its language. Surprisingly, the script for this language, has only four alphabets (A, G, C and T for DNA and A, G, C and U for RNA). This simplicity ingrained in the most complex language of the mortal world has always baffled me as a scientist. I am primarily interested in decrypting the script of life and mastering it modulate health and disease. Decoding the secret language will allow us to develop newer strategies to counter pathophysiological challenges in human beings by encoding and packaging new information in life?s own language. My earlier work involved studying the role of small RNA molecules (known as microRNAs) in the interactions of bone cells with microroughened titanium implant surfaces. Presently I am developing a research lab in the field of regenerative medicine wherein I?ll be using molecular biology tools to study human pathophysiological conditions and attempt to identify therapeutic tools.

Research

  • 1 Regenerative Medicine
  • 2 Clinical Research
  • 3 Bone Regeneration & Bone Tissue Engineering

Publications

  • Das S. S., Chakravorty N., Advances in Medicine and Biology, MicroRNAs in Beta-Thalassemia: Pathogenesis, Diagnosis and Treatment, 89-116, 2019
  • Das S. S., Chakravorty N., Analysis of miRNA, mRNA, and drug regulatory networks identify drug repurposing candidates to treat vascular occlusion in sickle cell disease, Inbix 19: Indian Conference on Bioinformatics, 2019
  • Das S. S., Mitra A. , Chakravorty N, Diseases and their clinical heterogeneity Are we ignoring the SNiPers and micRomaNAgers? An illustration using Beta-thalassemia clinical spectrum and fetal hemoglobin levels, Genomics, 111, 67-75, 2019
  • Das S. S., Chakravorty N, Identification of deleterious SNPs and their effects on BCL11A, the master regulator of fetal hemoglobin expression, Genomics, 2019
  • Das S. S., Sinha R. , Chakravorty N., Integrative microRNA and gene expression analysis identifies new drug repurposing candidates for fetal hemoglobin induction in - hemoglobinopathies, Gene, 77-83, 2019
  • Barik A., Choudhury . N., Chakravorty N, Parameter Optimization of Injectable Polycaprolactone Microspheres Containing Curcumin Using Response Surface Methodology, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'18, 147-150, 2018
  • Das S. ., Saha P. , Chakravorty N., miRwayDB: a database for experimentally validated microRNA-pathway associations in pathophysiological conditions, Database, 2018
  • Chakravorty N., Jaiprakash A. , Ivanovski S. , Xiao Y., Biomaterials for Implants and Scaffolds, Implant Surface Modifications and Osseointegration, 107-131, 2017
  • Das S. S., Chakravorty N., An in-silico prediction model to identify the functional effect of nsSNPs in HBB gene and their associated role in Beta-thalassemia, Inbix'17: Indian Conference on Bioinformatics 2017, 2017
  • Das S. S., Mitra A. , Chakravorty N., Genetic polymorphisms in microRNA genes: Implications in fetal hemoglobin regulation, Biospectrum (2017) - International Conference on Biotechnology and Biological Sciences, 2017
  • Barik A., Banerjee S. , Dhara S. , Chakravorty N, A Reductionist Approach to Extract Robust Molecular Markers from Microarray Data Series -Isolating Markers to Track Osseointegration, Journal of Biomedical Informatics, 2017
  • Barik A., Banerjee S. , Dhara S. , Chakravorty N, A Reductionist Approach to Extract Robust Molecular Markers from Microarray Data Series -Isolating Markers to Track Osseointegration, Journal of Biomedical Informatics, 68, 104-111, 2017
  • Das S. S., James M. , Paul S. , Chakravorty N, miRnalyze: an interactive database linking tool to unlock intuitive microRNA regulation of cell signaling pathways, Database, 2017
  • Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Rohit Gundamaraju, Rajeev K Singla, Prakash Katakam, Shanta K Adiki, Biswajoy Ghosh, Analava Mitra, Computational pharmacokinetics and in vitro-in vivo correlation of anti-diabetic synergistic phyto-composite blend, World Journal of Diabetes, 2015
  • Nishant Chakravorty, Stephen Hamlet, Anjali Jaiprakash, Ross Crawford, Adekunle Oloyede, Mohammed Alfarsi, Yin Xiao and Saso Ivanovski, Pro-osteogenic topographical cues promote early activation of osteoprogenitor differentiation via enhanced TGF?, Wnt and Notch signaling, Clinical and Oral Implants Research, 2014
  • Yinghong Zhou, Nishant Chakravorty, Yin Xiao and Wenyi Gu, Mesenchymal stem cells and nano-structured surfaces, Methods in Molecular Biology, 2013
  • Prasadam I., Chakravorty N. , Crawford R. , Xiao Y., Mesenchymal Stem Cells, Mesenchymal stem cells in osteoarthritis therapy: current status of theory, technology, and applications, 163-176, 2012
  • Chakravorty N., Ivanovski S. , Prasadam I. , Crawford R. , Oloyede A. , Xiao Y., The microRNA expression signature on modified titanium implant surfaces influences genetic mechanisms leading to osteogenic differentiation, Acta Biomaterialia, 2012
  • Ashalatha Ganesh, Nishant Chakravorty, Rashmi Mukherjee, Sourendrakanta Goswami, Koel Chaudhury and Baidyanath Chakravarty, Comparison of oral dydrogestrone with progesterone gel and micronized progesterone for luteal support in 1,373 women undergoing in vitro fertilization: a randomized clinical study, Fertility and Sterility, 95, 2011

Projects

  • A Biomimetic ECM Protein-based Bioadhesive Graft Copolymer for Implants - Targeting Enhanced Soft Tissue Integration and Osseointegration
  • MicroRNA based Reprogramming of Fetal Hemoglobin in Beta-Thalassemia
  • MHC Haplotypes in HBE/Beta Thalassemia: Correlating Disease Heterogeneity and Blood Transfusion Requirements in West Bengal
  • Development of a Portable Decision Support Tool for Screening and Refferal of High Risk Antenatal Cases at Household Level by Community Health Workers

Awards

  • Inst. Silv. Med.,IIT Kgp
  • Outstand.Doc.Thesis (SEF, QUT)
  • Outstand HDR stud. (SEF, QUT)
  • Young Sci.Amb.,ATSE, Australia

Research Group

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Anwesha Barik
Ph.D
Research Scholars
Implants and osseointegration
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Debleena Basu
Ph.D
Research Scholars
Thalassemia
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Lopa Mudra Das
Ph.D
Research Scholars
Development of a bioadhesive material for medical applications
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Motiur Rahaman
Ph.D
Research Scholars
New Approaches to Manage Beta-thalassemia
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Siva Prakasam O K
Ph.D
Research Scholars
Biosensor
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Sricheta Parui
Ph.D
Research Scholars
Human Computer Interaction