Research

• 1 Atherosclerosis and non-coding RNAs
• 2 Immune interaction in heart and vessels
• 3 Heart failure and vascular biology

Teaching

Publications

• Rituparna Chakrabarti, Sushmitha Duddu, Ashutosh Tiwari, K. Tejaswi Naidu, Pooja Sharma, Nishant Chakravorty, Praphulla Chandra Shukla, Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis, Life Sciences, 321, 121620, 2023
• Rahaman M, Mukherjee M, Bhattacharya S, Mukherjee B, Shukla PC, Dolai TK, Chakravorty N., Exploring the crosstalk between long non-coding RNAs and microRNAs to unravel potential prognostic and therapeutic biomarkers in ?-thalassemia, Mol Biol Rep, 2022
• Mukherjee M, Rahaman M, Ray SK, Shukla PC, Dolai TK, Chakravorty N., Revisiting fetal hemoglobin inducers in beta-hemoglobinopathies: a review of natural products, conventional and combinatorial therapies, Mol Biol Rep, 2022
• Duddu S, Agrawal M, Chakrabarti R, Ghosh A, Chakravorty N, Tiwari A, Shukla PC., Meta-analysis reveals inhibition of the inflammatory cytokine IL-6 affords limited protection post-myocardial ischemia/infarction., Heliyon, 8(8), 2022
• Bhattacharya A, Chowdhury A, Chaudhury K, Shukla PC., Proprotein convertase subtilisin/kexin type 9 (PCSK9): A potential multifaceted player in cancer, Biochim Biophys Acta Rev Cancer., 1876, 188581, 2021
• Loebel M, Holzhauser L, Hartwig JA, Shukla PC, Savvatis K, Jenke A, Skurk C. et.al,, The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance in myocarditis, European Heart Journal, 876-887, 2018
• Thompson, M.D., Mei, Y., Weisbrod, R.M., Silver, M., Shukla, P.C., Bolotina, V.M., Cohen, R.A., Tong, X, Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 regulate endothelial cell calcium stores and angiogenic function as well as promotes ischemic blood flow recovery, Journal of Biological Chemistry, 289, 2014
• P.C., Quan, A., Al-Omran, M., Lovren, F., Pan, Y., Brezden-Masley, C., Ingram, A.J., Stanford, W.L., Teoh, H., Verma, S., BRCA1 is a Novel Target to Improve Endothelial Dysfunction and Retard Atherosclerosis, Journal of Thoracic and Cardiovascular Surgery, 146, 2013
• Quan, A., Lovren, F, Pan, Y., Wagg, C. S., Teoh, H., Lopaschuk, G. D., Verma, S., Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1, Journal of Thoracic and Cardiovascular Surgery, 2013
• Desjardins, J-F., Lovren, F., Pan, Y., Garg, V., Gosal, S., Garg, A., Szmitko, P.E., Schneider, M.D., BRCA2 deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure, Journal of Biological Chemistry, 2012
• Shukla PC, Singh KK, Quan A, Al-Omran M, Teoh H, Lovren F, et.al.,, BRCA1 is an essential regulator of heart function and survival following myocardial infarction, Nature Communications, 2011
• Singh* K. K., Shukla* P. C, Herceptin, a recombinant humanized anti-ERBB2 monoclonal antibody, induces p53-mediated cardiomyocyte death, Biochem Biophys Res Commun, 411, 421-426, 2011
• Shukla P. C., DNA damage repair and cardiovascular diseases, Canadian Journal of Cardiology, 26, 13-16, 2010
• Praphulla Chandra Shukla, https://www.ncbi.nlm.nih.gov/sites/myncbi/1pC3aYNeKze5q/collections/45217560/public/, Please click the file to get all the articles

Projects

• Deubiquitinases in endothelial function
• Endothelial Function and Thrombotic Thrombocytopenia in SARS-CoV2
• Identification of Non-coding RNAs Regulation MLKL/RIPK3 Pathway in Vascular Smooth Muscle Cells: Role of Novel Non-coding RNAs in VSMC Necroptosis
• MicroRNA based Reprogramming of Fetal Hemoglobin in Beta-Thalassemia
• HC Haplotypes in HBE/Beta Thalassemia: Correlating Disease Heterogeneity and Blood Transfusion Requirements in West Bengal

Awards

Patents

Research Group

Pooja Sharma

Ph.D

Research Scholars

Deubiquitinases in endothelial function

Rituparna Chakrabarti

Ph.D

Research Scholars

Sushmitha Duddu

Ph.D

Research Scholars

Cardiovascular pathophysiology