Praphulla Chandra Shukla


Research Statement

We're new and evolving group, working on the areas of cell and molecular biology, medicine and genomics. 

Work is related to long-standing and current problems in: 
Molecular cardiology and vascular biology (Key words: heart failure, inflammation & atherosclerosis, apoptosis & novel modes of cell death, cardiac remodeling, regeneration, immunobiology of heart and vessels, non-coding RNAs) This involves from in vitro to in vivo modeling of heart related diseases. With the use of various primary cells and cell lines, genetically modified mice and surgery, we induce diseases & pathologically similar conditions to study cardiovascular problems at cellular level. 
Developmental biology (cardiac and vascular development during embryogenesis) With timed mating protocols and by using genetically modified mice, our focus is to study genes in cardiac development and diseases.


  • 1 Atherosclerosis and non-coding RNAs
  • 2 Immune interaction in heart and vessels
  • 3 Heart failure and vascular biology


  • Rituparna Chakrabarti, Sushmitha Duddu, Ashutosh Tiwari, K. Tejaswi Naidu, Pooja Sharma, Nishant Chakravorty, Praphulla Chandra Shukla, Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis, Life Sciences, 321, 121620, 2023
  • Rahaman M, Mukherjee M, Bhattacharya S, Mukherjee B, Shukla PC, Dolai TK, Chakravorty N., Exploring the crosstalk between long non-coding RNAs and microRNAs to unravel potential prognostic and therapeutic biomarkers in ?-thalassemia, Mol Biol Rep, 2022
  • Mukherjee M, Rahaman M, Ray SK, Shukla PC, Dolai TK, Chakravorty N., Revisiting fetal hemoglobin inducers in beta-hemoglobinopathies: a review of natural products, conventional and combinatorial therapies, Mol Biol Rep, 2022
  • Duddu S, Agrawal M, Chakrabarti R, Ghosh A, Chakravorty N, Tiwari A, Shukla PC., Meta-analysis reveals inhibition of the inflammatory cytokine IL-6 affords limited protection post-myocardial ischemia/infarction., Heliyon, 8(8), 2022
  • Bhattacharya A, Chowdhury A, Chaudhury K, Shukla PC., Proprotein convertase subtilisin/kexin type 9 (PCSK9): A potential multifaceted player in cancer, Biochim Biophys Acta Rev Cancer., 1876, 188581, 2021
  • Loebel M, Holzhauser L, Hartwig JA, Shukla PC, Savvatis K, Jenke A, Skurk C.,, The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance in myocarditis, European Heart Journal, 876-887, 2018
  • Thompson, M.D., Mei, Y., Weisbrod, R.M., Silver, M., Shukla, P.C., Bolotina, V.M., Cohen, R.A., Tong, X, Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 regulate endothelial cell calcium stores and angiogenic function as well as promotes ischemic blood flow recovery, Journal of Biological Chemistry, 289, 2014
  • P.C., Quan, A., Al-Omran, M., Lovren, F., Pan, Y., Brezden-Masley, C., Ingram, A.J., Stanford, W.L., Teoh, H., Verma, S., BRCA1 is a Novel Target to Improve Endothelial Dysfunction and Retard Atherosclerosis, Journal of Thoracic and Cardiovascular Surgery, 146, 2013
  • Quan, A., Lovren, F, Pan, Y., Wagg, C. S., Teoh, H., Lopaschuk, G. D., Verma, S., Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1, Journal of Thoracic and Cardiovascular Surgery, 2013
  • Desjardins, J-F., Lovren, F., Pan, Y., Garg, V., Gosal, S., Garg, A., Szmitko, P.E., Schneider, M.D., BRCA2 deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure, Journal of Biological Chemistry, 2012
  • Shukla PC, Singh KK, Quan A, Al-Omran M, Teoh H, Lovren F,,, BRCA1 is an essential regulator of heart function and survival following myocardial infarction, Nature Communications, 2011
  • Singh* K. K., Shukla* P. C, Herceptin, a recombinant humanized anti-ERBB2 monoclonal antibody, induces p53-mediated cardiomyocyte death, Biochem Biophys Res Commun, 411, 421-426, 2011
  • Shukla P. C., DNA damage repair and cardiovascular diseases, Canadian Journal of Cardiology, 26, 13-16, 2010
  • Praphulla Chandra Shukla,, Please click the file to get all the articles


  • Deubiquitinases in endothelial function
  • Endothelial Function and Thrombotic Thrombocytopenia in SARS-CoV2
  • Identification of Non-coding RNAs Regulation MLKL/RIPK3 Pathway in Vascular Smooth Muscle Cells: Role of Novel Non-coding RNAs in VSMC Necroptosis
  • MicroRNA based Reprogramming of Fetal Hemoglobin in Beta-Thalassemia
  • HC Haplotypes in HBE/Beta Thalassemia: Correlating Disease Heterogeneity and Blood Transfusion Requirements in West Bengal

Research Group

Card image
Anuran Ghosh
Research Scholars
Basic Cardiovascular Biology
Card image
Pooja Sharma
Research Scholars
Deubiquitinases in endothelial function
Card image
Rituparna Chakrabarti
Research Scholars
Card image
Sushmitha Duddu
Research Scholars
Cardiovascular pathophysiology