Pre-loader

Praphulla Chandra Shukla

About


Research Statement


We're new and evolving group, working on the areas of cell and molecular biology, medicine and genomics. 

Work is related to long-standing and current problems in: 
Molecular cardiology and vascular biology (Key words: heart failure, inflammation & atherosclerosis, apoptosis & novel modes of cell death, cardiac remodeling, regeneration, immunobiology of heart and vessels, non-coding RNAs) This involves from in vitro to in vivo modeling of heart related diseases. With the use of various primary cells and cell lines, genetically modified mice and surgery, we induce diseases & pathologically similar conditions to study cardiovascular problems at cellular level. 
Developmental biology (cardiac and vascular development during embryogenesis) With timed mating protocols and by using genetically modified mice, our focus is to study genes in cardiac development and diseases.
 

Research

  • 1 Atherosclerosis and non-coding RNAs
  • 2 Immune interaction in heart and vessels
  • 3 Cardiac developmental biology
  • 4 Heart failure and vascular biology

Publications

  • Stroux A. , Beling A. , Kespohl M. , Pinkert S. , Fechner H. , Kuehl U. , Lassner D. , Poller W. , Schultheiss H. , Zeller T. , Blankenberg S. , Papageorgiou A. , Heymans S. , Landmesser U. , Scheibenbogen C. , Skurk C., The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance in myocarditis, European Heart Journal, 876-887, 2018
  • Thompson, M.D., Mei, Y., Weisbrod, R.M., Silver, M., Shukla, P.C., Bolotina, V.M., Cohen, R.A., Tong, X, Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 regulate endothelial cell calcium stores and angiogenic function as well as promotes ischemic blood flow recovery, Journal of Biological Chemistry, 289, 2014
  • P.C., Quan, A., Al-Omran, M., Lovren, F., Pan, Y., Brezden-Masley, C., Ingram, A.J., Stanford, W.L., Teoh, H., Verma, S., BRCA1 is a Novel Target to Improve Endothelial Dysfunction and Retard Atherosclerosis, Journal of Thoracic and Cardiovascular Surgery, 146, 2013
  • Quan, A., Lovren, F, Pan, Y., Wagg, C. S., Teoh, H., Lopaschuk, G. D., Verma, S., Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1, Journal of Thoracic and Cardiovascular Surgery, 2013
  • Desjardins, J-F., Lovren, F., Pan, Y., Garg, V., Gosal, S., Garg, A., Szmitko, P.E., Schneider, M.D., BRCA2 deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure, Journal of Biological Chemistry, 2012
  • Singh* K. K., Shukla* P. C, Herceptin, a recombinant humanized anti-ERBB2 monoclonal antibody, induces p53-mediated cardiomyocyte death, Biochem Biophys Res Commun, 411, 421-426, 2011
  • Shukla P. C., DNA damage repair and cardiovascular diseases, Canadian Journal of Cardiology, 26, 13-16, 2010

Projects

  • Identification of Non-coding RNAs Regulation MLKL/RIPK3 Pathway in Vascular Smooth Muscle Cells: Role of Novel Non-coding RNAs in VSMC Necroptosis
  • MicroRNA based Reprogramming of Fetal Hemoglobin in Beta-Thalassemia
  • HC Haplotypes in HBE/Beta Thalassemia: Correlating Disease Heterogeneity and Blood Transfusion Requirements in West Bengal

Research Group

Card image
Anuran Ghosh
Ph.D
Research Scholars
Basic Cardiovascular Biology
Card image
Sushmitha Duddu
Ph.D
Research Scholars
Cardiovascular pathophysiology