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Santanu Dhara

About


Research Statement


BioMaterials and Tissue Engineering (BMTE) was established by Dr. Dhara in the year 2007 soon after joining SMST as faculty. BMTE Group has main emphasis on product development research based on fundamental understanding of cell–material interactions and in vivo response. Amongst different biomaterial aspects, BMTE group is working for the development of customized implants through various top down and bottom up fabrication strategies. Primarily, the group is developing permanent implants for rehabilitation and biodegradable implants for tissue regeneration. In this context, metal and ceramic based permanent implants like mandible, dental crown, cortical bone etc. are manufactured by near net shape fabrication (direct casting and green state machining) approach. Bioactivation/ surface modification of implants for biological fixation is another important area of research. Under regenerative medicine approach, this group is developing biodegradable/bioactive materials with nano-micro architecture for skin, bone and cartilage tissue engineering. Different factors like scaffold architecture, chemistry, dynamic and static conditions are studied to improve cell-material interactions towards stem cell differentiation into native tissue phenotypes. Also the group is exploring diverse natural resources for isolation of bioactive molecules, biopolymers and materials for better healthcare delivery. The group has activities from materials development, study of cell biology and biochemical assays in vitro and in vivo towards final product development.

Research

  • 1 Customized Scaffold Bioactivation
  • 2 Near Net Shape Forming
  • 3 Medical textile, Biopolymer modification
  • 4 Nanofibers and Nanoparticle - Healthcare
  • 5 Implants and Devices

Publications

  • Patra P., Seesala V. S., Soni S. R., Roy R. K., Dhara S. , Ghosh A. , Patra N. , Pal S, Biopolymeric pH-responsive fluorescent gel for in-vitro and in-vivo colon specific delivery of metronidazole and ciprofloxacin, European Polymer J., 114, 255-264, 2019
  • Das P., Ganguly S. , Maity P. P., Sristava H. K., Bose M. , Dhara S. , Bandyopadhyay S. , Das A. K., Banerjee S. , Das N. C, Converting waste Allium sativum peel to nitrogen and sulphur co-doped photoluminescence carbon dots for solar conversion, cell labeling, and photobleaching diligences: A path from discarded waste to value-added products, Journal of Photochemistry and Photobiology B: Biology, 197, 2019
  • Dutta A., Mukherjee K. , Dhara S. , Gupta S, Design of porous titanium scaffold for complete mandibular reconstruction: The influence of pore architecture parameters, Computers in Biology and Medicine, 31-41, 2019
  • Das P., Ganguly S. , Maity P. P., Bose M. , Mondal S. , Dhara S. , Das A. K., Banerjee S. , Das N. C, Waste chimney oil to nanolights: A low cost chemosensor for tracer metal detection in practical field and its polymer composite for multidimensional activity, J. Photochem. Photobiol. B, 56-67, 2018
  • Parekh A., Das D. , Das S. , Dhara S. , Biswas K. , Mandal M. , Das S, Bioimpedimetric analysis in conjunction with growth dynamics to differentiate aggressiveness of cancer cells, Scientific Reports, 8, 783-792, 2018
  • Das P., Ganguly S. , Mondal S. , Ghorai U. K., Maity P. P., Choudhary S. , Gangopadhyay S. , Dhara S. , Banerjee S. , Das N. C., Dual doped biocompatible multicolor luminescent carbon dots for bio labeling, UV-active marker and fluorescent polymer composite, Luminescence, 1135-1145, 2018
  • Ganguly S., Das P. , Maity P. , Mondal S. , Ghosh S. , Dhara S. , Das N. C, Green Reduced Graphene Oxide Toughened Semi-IPN Monolith Hydrogel as Dual Responsive Drug Release System: Rheological, Physico-Mechanical and Electrical Evaluations, The Journal of Physical Chemistry B, 122, 7201-7218, 2018
  • Kapat K., Rameshbabu A. P., Maity P. P., Mandal A. , Bankoti K. , Datta J. , Das D. K., Dey G. , Mandal M. , Dhara S, Osteochondral Defects Healing Using Extracellular Matrix Mimetic Phosphate/Sulfate Decorated GAGs-Agarose Gel and Quantitative Micro-CT Evaluation, ACS Biomaterials Science & Engineering, 149-164, 2018
  • Ganguly S., Maity P. , Mondal S. , Bhawal P. , Dhara S. , Das N. C, Polysaccharide and poly(methacrylic acid) based biodegradable elastomeric biocompatible semi-IPN hydrogel for controlled drug delivery, Materials Science and Engineering: C, 34-51, 2018
  • Rameshbabu A. P., Bankoti K. , Dutta S. , Subramani E. , Apoorva A. , Ghosh P. , Maity P. P., Manchikanti P. , Chaudhury K. , Dhara S, Silk Sponges Ornamented with a Placenta-Derived Extracellular Matrix Augment Full-Thickness Cutaneous Wound Healing by Stimulating Neovascularization and Cellular Migration, ACS Applied Materials and Interfaces, 16977-16991, 2018
  • Kapat K., Maity P. P., Rameshbabu A. P., Srivas P. K., Majumdar P. , Dhara S., Simultaneous Hydrothermal Bioactivation with Nano-topographic Modulation of Porous Titanium Alloy towards Enhanced Osteogenic and Antimicrobial Responses, J Mat. Chem B, 2877-2893, 2018
  • Ghosh P., Rameshbabu A. P., Das D. , Subramanian B. , Samanta S. K., Roy S. , Pal S. , Ghosh S. K., Dhara S., Single-pot biofabrication of living fibers for tissue engineering applications, J Mat. Res, 2019-2028, 2018
  • Guha Ray P., Pal P. , Srivas P. K., Basak P. , Roy S. , Dhara S., Surface Modification of Eggshell Membrane with Electrospun Chitosan/Polycaprolactone Nanofibers for Enhanced Dermal Wound Healing, ACS Applied Bio Materials, 985-998, 2018
  • Das P., Ganguly S. , Maity P. , Bose M. , Mondal S. , Dhara S. , Das A. K., Banerjee S. , Das N. C, Waste chimney oil to nanolights: A low cost chemosensor for tracer metal detection in practical field and its polymer composite for multidimensional activity, Journal of Photochemistry and Photobiology B: Biology, 56-67, 2018
  • Chakrabirty R., Seesala V. S., Sen M. , Sengupta S. , Dhara S. , Saha P. , Das K. , Das S., MWCNT reinforced bone like calcium phosphate Hydroxyapatite composite coating developed through pulsed electrodeposition with varying amount of apatite phase and crystallinity to promote superior osteoconduction, cytocompatibility and corrosion protection performance compared to bare metallic implant surface, Surface and Coatings Technology, 496-514, 2017
  • Datta S., Rameshbabu A. P., Bankoti K. , Maity P. P., Das D. , Pal S. , Roy S. , Sen R. , Dhara S, Oleoyl chitosan based nanofiber mats impregnated with amniotic membrane derived stem cells for accelerated full-thickness excisional wound healing, ACS Biomaterials Science and Engineering, 1738-1749, 2017
  • Selvakumar M., Srivas P. K., Das B. , Dhara S. , Chattopadhyay S, Structurally Tuned Antimicrobial Mesoporous Hydroxyapatite Nanorods by Cyclic Oligosaccharides Regulation to Release of Drug for Osteomyelitis, Crystal Growth and Design, 17, 433-445, 2017
  • Roy A., Dadhich P. , Dhara S. , De S., Understanding and Tuning of Polymer Surfaces for Dialysis Applications, Polymers for Advanced Technologies, 84, 174-187, 2017
  • Mandal B., Das D. , Rameshbabu A. P., Dhara S. , Pal S, A Biodegradable, biocompatible transdermal device derived from carboxymethyl cellulose and multi-walled carbon nanotube for sustained release of diclofenac sodium, RSC Advances, 19605-19611, 2016
  • P. Dadhich, B. Das, P. Pal, P. K Srivas, J. Dutta, S. Ray, and S. Dhara, A Simple Approach for Eggshells based 3D Printed Osteoinductive Multi-phasic Calcium Phosphate Scaffold, ACS Appl. Mater. Interfaces, 2016
  • Kalita H., Pal P. , Dhara S. , Pathak A., Fabrication and Characterization of Polyvinyl alcohol/Metal (Ca, Mg, Ti) Doped Zirconium Phosphate Nanocomposite Films for Scaffold-guided Tissue Engineering Application, Materials Science & Engineering:C (Mater. for Bio. Appl.), 71, 363-371, 2016
  • Sen S., Konar S. , Das B. , Pathak A. , Dhara S. , Dasgupta S. , Dasgupta S, Inhibition of fibrillation of Human Serum Albumin through interaction with Chitosan-based Biocompatible Silver Nanoparticles, RSC Advances, 43104-43115, 2016
  • Majumdar P., Singh S. B., Dhara S. , Chakraborty M., Influence of boron addition to Ti 13Zr 13Nb alloy on MG63 osteoblast cell viability and protein adsorption, Materials Science and Engineering C, 42, 62-68, 2015
  • Roy A., Dadhich P. , Dhara S. , De S, In Vitro Cytocompatibility and Blood Compatibility for Polysulfone blend, surface modified polysulfone and Polyacrylonitrile membranes for hemodialysis, RSC Advances, 7023-7034, 2015
  • P. Ghosh, M. Das, A. P. Rameshbabu, D. Das, S. Datta, S. Pal, A. B. Panda, and S. Dhara, Chitosan Derivatives Cross-Linked with Iodinated 2,5-Dimethoxy-2,5-dihydrofuran for Non-Invasive Imaging, ACS Appl. Mater. Interfaces, 2014
  • P. Ghosh, A. P. Ramesh babu, and S. Dhara, Citrate Cross-Linked Gels with Strain Reversibility and Viscoelastic Behavior Accelerate Healing of Osteochondral Defects in a Rabbit Model, Langmuir, 8442-8451, 2014
  • Mukherjee S., Dhara S. , Saha P, Influence Of Surface Roughness Parameters On Mg63 Cell Viability: A Study On Laser Microtextured Ti6Al4V Surfaces, The International Journal of Artificial Organs, 2014
  • S. Dey Sarkar, B. Farrugia, T. Dargaville, S. Dhara, Chitosan-collagen scaffolds with nano/micro fiber architecture for skin tissue engineering application, J. Biomedical Materials Research, Part A, 3482-3492, 2013
  • P. Datta, P. Ghosh, K. Ghosh, P. Maiti, S. K. Samanta, S. K. Ghosh, P. K. Das Mohapatra, J. Chatterjee, S Dhara, In Vitro ALP and Osteocalcin Gene Expression Analysisand In Vivo Biocompatibility of N-Methylene PhosphonicChitosan Nanofibers for Bone Regeneration, Journal of Biomedical Nanotechnology, 9, 1-10, 2013
  • S. Mohanty, A. P. Rameshbabu, S. Dhara, Alpha-Alumina Fiber with Platelet Morphology through Wet Spinning, J. Am. Ceram. Soc, 94, 1234-1240, 2012
  • Majumdar P., Singh S. B., Dhara S. , Chakraborty M., Influence of in situ TiB Reinforcements and Role of Heat Treatment on Mechanical Properties and Biocompatibility of beta Ti-alloy, Journal of the Mechanical Behavior of Biomedical Materials, 10, 1-12, 2012
  • F. Pati, B. Adhikari, S. Dhara, Isolation and characterization of fish scale collagen of higher thermal stability, Bioresource Technology, 101, 3737-3742, 2010

Projects

  • Mechanical characterization of ophthalmic implants: A case study
  • Development of Bioactive 3D Scaffold with Nano/Micro Hierchy for Bone Tissue Engineering Through Combinatorial Approach
  • Multi - layer customized skin graft for full thickness wound
  • Development of Titanium lattice structured implant for joint replacement
  • Direct printing of bioresorbable radiopaque polymeric stent: A novel approach for lumen stricture
  • Fabrication of Hydroxyapatite discs
  • Development of dense and porous Titanium components via powder metallurgy route for biomedical applications
  • Signals & systems for life science
  • Micro/Nano manufacturing and characterization facility for robotics in nano-scale manipulation
  • Miniature active device for guidance of intracoronary Angioplasty wires, Catheters & Stents
  • Fabrication of Hydroxyapatite discs
  • Involvement of functional single nucleotide polymorphisms (SNP) of matrix metalloproteinase (MMP) gene promoters in the cell type specific regulation of human MMPs: intrinsic genetic characteristics in cancer cell progression

Awards

  • BIRAC SRISTI GYTI award, 2015
  • DST-Lockheed Martin India 2015
  • DST-Lockheed Martin India 2016
  • EPSRC fellowship UK
  • Incubiz Anveshan IIM Ahmedabad

Research Group

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Abir Dutta
Ph.D
Research Scholars
Biomechanics and Biomaterials
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Ankit Porwal
Ph.D
Research Scholars
Laser additive manufacturing of bio compatible materials
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Anurag Kumar Pandey
Ph.D
Research Scholars
Synthesis and Characterization of Nanoparticles for Biomedical and Energy Harvesting Applications
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Basil Mathai
Ph.D
Research Scholars
Biomechanics and Biomaterials
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Lakshmi M Mukundan
Ph.D
Research Scholars
Polymer-bioactive glass composites for biomedical applications
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Pravin Vaidya
Ph.D
Research Scholars
Powder Processing
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Ragavi. R
Ph.D
Research Scholars
Health Care Management
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Rahul Gautam Talukdar
Ph.D
Research Scholars
Biomechanics and Biomaterials
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Siva Prakasam O K
Ph.D
Research Scholars
Biosensor
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Trina Roy
Ph.D
Research Scholars
Bioresorbable Vascular graft
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Varisha Farheen
Ph.D
Research Scholars
Drug and bioactive delivery systems
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Venkata Sundeep S
Ph.D
Research Scholars
Dental and Tissue Engineering